才华横溢且高傲自信的外科女医生卡罗琳·泰勒（詹妮弗·比尔斯 Jennifer Beals 饰）是一个彻彻底底的无神论主义者，数年前的海难中她失去了儿子威尔，此外她更在昏迷中经历了濒死体验，只不过决然不相信所谓灵魂方面的说辞。某日，她被院长命令与IT界的顶尖精英伊万·杜林（马修·莫迪恩 Matthew Modine 饰）见面，伊万自称病入膏肓，他承诺将全部财产捐给卡罗琳所在的医院，条件是对方配合他进行灵魂及濒死体验方面的研究。起初卡罗琳对此极为抵触，但经过一系列事件后，她抱着试试看的态度与伊万合作，并且找到非洲来的实习生泽丹（Edi Gathegi 饰）以及伊万的下属雅内尔（Caroline Rose Kaplan 饰）担任助手。 神秘未知的世界是否存在？死亡是否就是灵魂之旅的终点？
Season one follows BEE, a jaded girl who plays a self-destructive game of hooking up with as many straight girls as possible, much to the disapproval of her best friend and roommate, OLIVIA--whose enemy #1 is the cooler than cool EDISON from down the hall. Bee's newest target is the fairytale romance-loving DYLAN. Bee is determined to win the game, even though Dylan's boyfriend, GARY, and--could it be?-- feelings stand in the way. Will she listen to Olivia in time? Or is heartbreak on the horizon?!!!!.
Season three kicks off for Homicide Inspectors Terry English and Hildy Mulligan when an all-star quarterback is murdered in the middle of a crowded club in front of his pop star girlfriend. D.A. Mario Siletti and his wife are involved in a tragic car accident that could end his career and his marriage. And an untimely diagnosis threatens Hildy's future.